Duke Human Vaccine Institute

Kevin Wiehe (Bioinformatics Team)
Associate Professor in Medicine

Contact Info

(919) 684-2320

Location

106 Research Dr, MSRBII Box 103020
Durham, NC 27710

Department / Division

Assistant Professor in Medicine

Training

Ph.D., Boston University (2007)

Representative Publications

Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants. (03/2020)
Martinez, DR; Tu, JJ; Kumar, A; Mangold, JF; Mangan, RJ; Goswami, R; Giorgi, EE; Chen, J; Mengual, M; Douglas, AO; Heimsath, H; Saunders, KO; Nicely, NI; Eudailey, J; Hernandez, G; Morgan-Asiedu, PK; Wiehe, K; Haynes, BF; Moody, MA; LaBranche, C; Montefiori, DC; Gao, F; Permar, SR
Immune checkpoint modulation enhances HIV-1 antibody induction. (02/2020)
Bradley, T; Kuraoka, M; Yeh, C-H; Tian, M; Chen, H; Cain, DW; Chen, X; Cheng, C; Ellebedy, AH; Parks, R; Barr, M; Sutherland, LL; Scearce, RM; Bowman, CM; Bouton-Verville, H; Santra, S; Wiehe, K; Lewis, MG; Ogbe, A; Borrow, P; Montefiori, D; Bonsignori, M; Anthony Moody, M; Verkoczy, L; Saunders, KO; Ahmed, R; Mascola, JR; Kelsoe, G; Alt, FW; Haynes, BF
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. (12/2019)
Saunders, KO; Wiehe, K; Tian, M; Acharya, P; Bradley, T; Alam, SM; Go, EP; Scearce, R; Sutherland, L; Henderson, R; Hsu, AL; Borgnia, MJ; Chen, H; Lu, X; Wu, NR; Watts, B; Jiang, C; Easterhoff, D; Cheng, H-L; McGovern, K; Waddicor, P; Chapdelaine-Williams, A; Eaton, A; Zhang, J; Rountree, W; Verkoczy, L; Tomai, M; Lewis, MG; Desaire, HR; Edwards, RJ; Cain, DW; Bonsignori, M; Montefiori, D; Alt, FW; Haynes, BF
Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies. (12/2019)
LaBranche, CC; Henderson, R; Hsu, A; Behrens, S; Chen, X; Zhou, T; Wiehe, K; Saunders, KO; Alam, SM; Bonsignori, M; Borgnia, MJ; Sattentau, QJ; Eaton, A; Greene, K; Gao, H; Liao, H-X; Williams, WB; Peacock, J; Tang, H; Perez, LG; Edwards, RJ; Kepler, TB; Korber, BT; Kwong, PD; Mascola, JR; Acharya, P; Haynes, BF; Montefiori, DC
Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage. (09/2019)
Sacks, D; Bhiman, JN; Wiehe, K; Gorman, J; Kwong, PD; Morris, L; Moore, PL
Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies. (09/2019)
LaBranche, CC; Henderson, R; Hsu, A; Behrens, S; Chen, X; Zhou, T; Wiehe, K; Saunders, KO; Alam, SM; Bonsignori, M; Borgnia, MJ; Sattentau, QJ; Eaton, A; Greene, K; Gao, H; Liao, H-X; Williams, WB; Peacock, J; Tang, H; Perez, LG; Edwards, RJ; Kepler, TB; Korber, BT; Kwong, PD; Mascola, JR; Acharya, P; Haynes, BF; Montefiori, DC
HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers. (07/2019)
Nyanhete, TE; Frisbee, AL; Bradley, T; Faison, WJ; Robins, E; Payne, T; Freel, SA; Sawant, S; Weinhold, KJ; Wiehe, K; Haynes, BF; Ferrari, G; Li, Q-J; Moody, MA; Tomaras, GD
Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies. (02/2019)
Henderson, R; Watts, BE; Ergin, HN; Anasti, K; Parks, R; Xia, S-M; Trama, A; Liao, H-X; Saunders, KO; Bonsignori, M; Wiehe, K; Haynes, BF; Alam, SM
Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. (01/2019)
Kisalu, NK; Idris, AH; Weidle, C; Flores-Garcia, Y; Flynn, BJ; Sack, BK; Murphy, S; Schön, A; Freire, E; Francica, JR; Miller, AB; Gregory, J; March, S; Liao, H-X; Haynes, BF; Wiehe, K; Trama, AM; Saunders, KO; Gladden, MA; Monroe, A; Bonsignori, M; Kanekiyo, M; Wheatley, AK; McDermott, AB; Farney, SK; Chuang, G-Y; Zhang, B; Kc, N; Chakravarty, S; Kwong, PD; Sinnis, P; Bhatia, SN; Kappe, SHI; Sim, BKL; Hoffman, SL; Zavala, F; Pancera, M; Seder, RA
Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses. (01/2019)
Tay, MZ; Wiehe, K; Pollara, J

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