Kevin Wiehe (Bioinformatics Team)

Assistant Professor in Medicine

Contact Info

(919) 684-2320

Location

106 Research Dr, MSRBII Box 103020
Durham, NC 27710

Department / Division

Assistant Professor in Medicine

Training

Ph.D., Boston University (2007)

Representative Publications

Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage. (09/2019)

Sacks, D; Bhiman, JN; Wiehe, K; Gorman, J; Kwong, PD; Morris, L; Moore, PL

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies. (09/2019)

LaBranche, CC; Henderson, R; Hsu, A; Behrens, S; Chen, X; Zhou, T; Wiehe, K; Saunders, KO; Alam, SM; Bonsignori, M; Borgnia, MJ; Sattentau, QJ; Eaton, A; Greene, K; Gao, H; Liao, H-X; Williams, WB; Peacock, J; Tang, H; Perez, LG; Edwards, RJ; Kepler, TB; Korber, BT; Kwong, PD; Mascola, JR; Acharya, P; Haynes, BF; Montefiori, DC

HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers. (07/2019)

Nyanhete, TE; Frisbee, AL; Bradley, T; Faison, WJ; Robins, E; Payne, T; Freel, SA; Sawant, S; Weinhold, KJ; Wiehe, K; Haynes, BF; Ferrari, G; Li, Q-J; Moody, MA; Tomaras, GD

Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies. (02/2019)

Henderson, R; Watts, BE; Ergin, HN; Anasti, K; Parks, R; Xia, S-M; Trama, A; Liao, H-X; Saunders, KO; Bonsignori, M; Wiehe, K; Haynes, BF; Alam, SM

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. (01/2019)

Kisalu, NK; Idris, AH; Weidle, C; Flores-Garcia, Y; Flynn, BJ; Sack, BK; Murphy, S; Schön, A; Freire, E; Francica, JR; Miller, AB; Gregory, J; March, S; Liao, H-X; Haynes, BF; Wiehe, K; Trama, AM; Saunders, KO; Gladden, MA; Monroe, A; Bonsignori, M; Kanekiyo, M; Wheatley, AK; McDermott, AB; Farney, SK; Chuang, G-Y; Zhang, B; Kc, N; Chakravarty, S; Kwong, PD; Sinnis, P; Bhatia, SN; Kappe, SHI; Sim, BKL; Hoffman, SL; Zavala, F; Pancera, M; Seder, RA

Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses. (01/2019)

Tay, MZ; Wiehe, K; Pollara, J

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier. (12/2018)

Bonsignori, M; Scott, E; Wiehe, K; Easterhoff, D; Alam, SM; Hwang, K-K; Cooper, M; Xia, S-M; Zhang, R; Montefiori, DC; Henderson, R; Nie, X; Kelsoe, G; Moody, MA; Chen, X; Joyce, MG; Kwong, PD; Connors, M; Mascola, JR; McGuire, AT; Stamatatos, L; Medina-Ramírez, M; Sanders, RW; Saunders, KO; Kepler, TB; Haynes, BF

V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity. (12/2018)

van Eeden, C; Wibmer, CK; Scheepers, C; Richardson, SI; Nonyane, M; Lambson, B; Mkhize, NN; Vijayakumar, B; Sheng, Z; Stanfield-Oakley, S; Bhiman, JN; Bekker, V; Hermanus, T; Mabvakure, B; Ismail, A; Moody, MA; Wiehe, K; Garrett, N; Karim, SA; Dirr, H; Fernandes, MA; Sayed, Y; Shapiro, L; Ferrari, G; Haynes, BF; Moore, PL; Morris, L

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development. (06/2018)

Wiehe, K; Bradley, T; Meyerhoff, RR; Hart, C; Williams, WB; Easterhoff, D; Faison, WJ; Kepler, TB; Saunders, KO; Alam, SM; Bonsignori, M; Haynes, BF

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. (05/2018)