David Montefiori, PhD   Faculty Central
monte@duke.edu

David C. Montefiori, Ph.D. is a Research Professor and Director of the Laboratory for AIDS Vaccine Research and Development in the Department of Surgery at Duke University Medical Center.  His major research interests are viral immunology and AIDS vaccine development, with a special emphasis on neutralizing antibodies.  His highest priority is to identify immunogens that generate broadly cross-reactive neutralizing antibodies for inclusion in HIV-1 vaccines.  His laboratory studies the neutralizing antibody response in HIV-1 infected people and SIV and SHIV infected nonhuman primates with the aim of assessing the protective value of the response and designing assays that accurately predict this value. 

 

His laboratory has served as a national and international resource for assessing neutralizing antibodies in preclinical and clinical trials of candidate AIDS vaccines for the past 18 years, having performed the majority of neutralizing antibody assays for human clinical trials conducted by the AIDS Vaccine Evaluation Group (AVEG) and HIV Vaccine Trials Network (HVTN) since 1988.  His laboratory also functions as an NIH-sponsored immune monitoring laboratory for animal models, where he has assessed the neutralizing antibody response in over 350 preclinical AIDS vaccine studies since 1993. 

 

He has published over 200 original research papers that have helped shape the scientific rationale for new HIV-1 vaccine immunogens.  He is a member of the editorial board for Journal of Virology and Virology and he serves on External Scientific Advisory Committees for NIH-sponsored HIV-1 vaccine programs at several academic and private institutions.  He also serves on the Scientific Advisory Board for AlphaVax, Inc., the Board of Scientific Counselors for the NIH Vaccine Research Center, and on several advisory committees for the Division of AIDS, NIH.